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nhau

Abstract

Melanoma inongori chete ne4% yekenza dzese dzeganda asi iri pakati peanonyanya kuuraya mapundu. Dacarbazine ndiwo mushonga wesarudzo yekurapa melanoma muBrazil kuburikidza nehutano hweveruzhinji kunyanya nekuda kwemutengo wayo wakaderera. Nekudaro, iri alkylating mumiririri wepasi yakatarwa uye inokonzeresa kurapa kupindura mune chete 20% yematambudziko. Mimwe mishonga inowanikwa yekurapa melanoma inodhura, uye tumarara maseru anowanzo kuve nekupokana nemishonga iyi. Kurwisa melanoma kunoda nganonyorwa, yakanyanya madhiragi anoshanda mukuuraya mishonga inodzivirira mishonga. Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) zvigadzirwa zviri kuvimbisa antitumor vamiririri. Muchidzidzo ichi, isu takaongorora iyo cytotoxic mhedzisiro ye1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) paB16F10 maseru ehurwere pamwe nekubatana kwayo kwakanangana nemolekuru reDNA vachishandisa tweezers. DPBP yakaratidza mhedzisiro inovimbisa inopokana nemaseru maseru uye yaive neyekusarudzika indekisi ye41.94. Zvakare, isu takaratidza kugona kweDPBP yekudyidzana zvakananga neiyo DNA molecule. Icho chokwadi chekuti DPBP inogona kusangana neDNA in vitro inotibvumidza kufungidzira kuti kusangana kwakadaro kunogona kuitikawo mu vivo uye, nekudaro, kuti DPBP inogona kunge iri imwe nzira yekurapa varwere vane melanomas inopesana nemushonga. Izvi zvakawanikwa zvinogona kutungamira kuvandudzwa kwemishonga mitsva uye inoshanda.

Mifananidzo isinganzwisisike

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Plot yezana muzana yesero kufa yakawanikwa yeDPBP komputa inopesana nemelan-A uye B16F10 mitsara mumatunhu akasiyana. Iyo yakasarudzika indices (SI = IC50 melan-A / IC50 B16F10) yaive 41.94.                    

Yakabudiswa naElsevier BV

Abstract

Dibenzoylmethane (DBM) inhengo diki ye licorice uye β-diketone analogue ye curcumin. Kudyisa 1% DBM mukudya kune Sencar mbeva panguva dzese dzekutanga uye nguva dzekutangisa dzakatadzisa zvakanyanya 7,12-dimethylbenz [a] anthracene (DMBA) -yakakonzera mammary bundu kuwanda uye mammary bundu chiitiko ne97%. Mukuenderera mberi muzvidzidzo zve vivo kujekesa nzira dzinogona kuitika dzekudzivirira chiito cheDBM, kudyisa iyo 1% DBM mukudya kweAIN-76A kusakura mbeva dzeSencar kwemasvondo mana kusvika mashanu kwakaderedza uremu hwehutete hwechibereko ne43%, kwakatadzisa huwandu hwekuwedzera yemammary gland epithelial maseru ne53%, uterine epithelium ne23%, uye uterine stroma ne77%, apo mbeva dzakaurayiwa panguva yekutanga estrus chikamu cheestrous kutenderera. Uye zvakare, kupa 1% DBM mukudya kune Sencar mbeva pamasvondo maviri zvisati zvaitika, panguva uye 1 vhiki mushure mekurapwa kweDMBA (intubation ye1 mg DMBA pamushonga kamwe chete pavhiki kwemavhiki mashanu) yakadzivisa kugadzirwa kwehuwandu hweDMBA- DNA inowedzera mammary gland ne72% vachishandisa post-32P-yekunyorera muyedzo. Nekudaro, kudyisa 1% DBM chikafu kuSencar mbeva dzakadzivirirwa kuumbwa kweDMBA-DNA inowedzera mumatomu emammary uye yakadzora huwandu hwekuwedzera kweiyo mammary gland mu vivo. Mhedzisiro iyi inogona kutsanangura yakasimba yekudzivirira zviito zvekudya DBM pane mammary carcinogenesis mumakonzo.


Post nguva: Aug-12-2020